decamethonium是什么意思，decamethonium翻译

decamethonium是什么意思，decamethonium翻译

Decamethonium: A Potent Neuromuscular Blocker

Decamethonium, a chemical compound with the molecular formula C\(_{10}\)H\(_{20}\)N\(_{2}\)O\(_{2}\), is a potent neuromuscular blocking agent widely used in clinical settings for the induction and maintenance of muscle relaxation during surgical procedures. Its unique chemical structure, consisting of ten carbon atoms, two nitrogen atoms, and two oxygen atoms, gives it remarkable pharmacological properties that make it an effective muscle relaxant.

The discovery of decamethonium dates back to the early 20th century, when scientists were searching for new chemical compounds with anesthetic properties. In 1922, the German chemist Otto4 Wolfgang Luebbecke synthesized decamethonium by reacting chlorethyl ether with sodium methoxide. Subsequently, in the 1940s, British pharmacologist Henry Hallett Dale and his colleagues at the University of Edinburgh conducted extensive research on the compound's pharmacological effects, leading to its clinical use as a muscle relaxant.

Decamethonium exerts its neuromuscular blocking action by competitively binding to the cholinergic nicotinic acetylcholine receptors present at the neuromuscular junction. These receptors are responsible for the transmission of nerve impulses from motor neurons to muscle fibers, leading to muscle contraction. By occupying these receptors, decamethonium prevents the binding of acetylcholine, the neurotransmitter responsible for initiating muscle contractions. Consequently, muscle relaxation is induced, which is crucial during surgical procedures to maintain a stable and relaxed muscle tone, allowing surgeons to perform precise manipulations.

One of the key advantages of decamethonium is its rapid onset of action, which typically occurs within 1