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diphenylformamide是什么意思,diphenylformamide翻译
Diphenylformamide: An Overview
Diphenylformamide, commonly known as DPF, is an organic compound with the molecular formula C14H12N2O. It is a white crystalline solid that is sparingly soluble in water and readily soluble in organic solvents such as ethanol and dichloromethane. DPF is primarily used as a precursor in the synthesis of pharmaceuticals, particularly in the production of antihistamines, which are medications used to treat allergies.
History and Properties
Diphenylformamide was first synthesized in 1894 by the German chemist Paul Ehrlich. It was one of the first compounds to be used in the systematic synthesis of organic compounds with the intention of creating new drugs. DPF has a benzene ring fused to a formamide group, which gives it its unique chemical properties. The molecule has a melting point of around 156°C and a boiling point of approximately 325°C.
Synthesis and Reactions
The synthesis of diphenylformamide typically involves the reaction between diphenylamine and formamide in the presence of a base, such as sodium hydroxide. The reaction is carried out in an aqueous medium at a temperature of around 100°C. The resulting diphenylformamide can then be isolated by filtration and dried.
DPF can also undergo various chemical reactions, such as nucleophilic substitution, electrophilic substitution, and addition reactions. These reactions can be used to modify the structure of the molecule, leading to the creation of new compounds with different properties. For example, the substitution of the formamide group with other functional groups can result in the formation of new drugs with altered pharmacological activities.
Pharmacological Effects
Diphenylformamide and its derivatives have been found to exhibit anticonvulsant, anxiolytic, and sedative properties. This is due to their ability to modulate the activity of certain neurotransmitter receptors, such as GABA receptors, which are involved in regulating neuronal excitability and mood.
However, DPF and its derivatives can also have toxic effects, particularly at higher concentrations. They have been found to be cytotoxic to various cell types, including cancer cells and immune cells. Additionally, they can cause oxidative stress and DNA damage, which can lead to mutations and cell death.
Conclusion
Diphenylformamide is an important compound in the field of organic chemistry, serving as a precursor for the synthesis of pharmaceuticals. Its unique structure and chemical properties allow for the creation of new drugs with a range of pharmacological activities. However, the potential cytotoxic and mutagenic effects of DPF and its derivatives must be considered when using them in pharmaceutical research and development.