fibrogenesis是什么意思，fibrogenesis翻译

fibrogenesis是什么意思，fibrogenesis翻译

Fibrogenesis: The Silent Enemy in Chronic Disease

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Introduction

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Fibrogenesis, the process by which connective tissue is formed, plays a critical role in the healing process. However, when this process becomes dysregulated, it can lead to fibrosis, a condition characterized by the excessive formation of connective tissue. Fibrosis can occur in various organs and tissues, leading to a range of chronic diseases, including liver cirrhosis, chronic obstructive pulmonary disease (COPD), and kidney fibrosis. In this article, we will explore the mechanisms behind fibrogenesis, its implications in chronic disease, and the current strategies for preventing and treating fibrosis.

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Mechanisms of Fibrogenesis

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Fibrogenesis is a complex process involving multiple cellular and molecular pathways. At its core, fibrogenesis is driven by activated fibroblasts, also known as myofibroblasts, which produce excessive amounts of collagen and other extracellular matrix proteins. These proteins accumulate in the tissue, leading to fibrosis.

One of the key drivers of fibrogenesis is transforming growth factor